Mostrando recursos 1 - 20 de 28.527

  1. ETHICS AND THE SCEPTICAL CHALLENGE: A PRAGMATICIST APPROACH

    Ética Desafio; Cético Uma; Abordagem Pragmaticista; Claudine Tiercelin
    Abstract: The aim of the paper is to present the specific reasons why a Peircian or pragmaticist approach is best “equipped ” not so much as compared with other pragmatist attempts, but as such, to answer some of the hardest challenges posed by contemporary scepticism, even when it comes to the ethical aspects posed by such a challenge. After sketching the major aspects of the sceptical challenge and the most common contemporary answers it gave rise to, an analysis is made of the reasons why the ethical aspect of the challenge is specifically acute, and why, then, in many ways,...

  2. novas trilhas

    Maria Helena; Lima Hatschbach; Gilda Olinto
    Resumo: Apresenta a evolução do enfoque do conceito, dos estudos e das práticas de Competência em Informação (Information Literacy) nos últimos trinta anos, numa trajetória que aborda desde o desenvolvimento de habilidades no uso de ‘fontes de informação’, de ‘técnicas e métodos de estudo e pesquisa’, de ‘tecnologias de informação e comunicação’, até a instrução bibliográfica e mesmo questões de ordem ética (direito autoral) e social (inclusão digital). A América Latina começa a se inserir e a atuar neste campo de maneira mais efetiva, em termos de programas institucionais e pesquisas acadêmicas, o que contribui para abordagens amplas e transdisciplinares...

  3. Search tags: Information Systems Administration – Moral and ethical aspects, Communication ethics,


    Descriptores: Administración de sistemas de informa-ción – aspectos morales y éticos, ética de la comuni-cación, materiales no-libro, medios de comunicación de masas y cultura.

  4. Broeckhoven C: Current status on Alzheimer disease molecular genetics: from past, to present, to future. Hum Mol Genet

    Karolien Bettens; Kristel Sleegers; Christine Van Broeckhoven
    Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer’s disease (AD). Yet, besides the three causal genes—amyloid precursor protein and presenilin 1 and 2 genes—and one risk gene apolipoprotein E (APOE), no single func-tional risk variant was identified. Discussing the possible involvement of rare alleles and other types of gen-etic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.

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  6. Broeckhoven C: Current status on Alzheimer disease molecular genetics: from past, to present, to future. Hum Mol Genet

    Karolien Bettens; Kristel Sleegers; Christine Van Broeckhoven
    Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer’s disease (AD). Yet, besides the three causal genes—amyloid precursor protein and presenilin 1 and 2 genes—and one risk gene apolipoprotein E (APOE), no single func-tional risk variant was identified. Discussing the possible involvement of rare alleles and other types of gen-etic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.

  7. The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine

    Rasa Sukackaite; Saulius Grazulis; Gintautas Tamulaitis; Virginijus Siksnys
    DNA cytosine methylation is a widespread epigen-etic mark. Biological effects of DNA methylation are mediated by the proteins that preferentially bind to 5-methylcytosine (5mC) in different sequence contexts. Until now two different structural mechan-isms have been established for 5mC recognition in eukaryotes; however, it is still unknown how discrimination of the 5mC modification is achieved in prokaryotes. Here we report the crystal structure of the N-terminal DNA-binding domain (McrB-N) of the methyl-specific endonuclease McrBC from Escherichia coli. The McrB-N protein shows a novel DNA-binding fold adapted for 5mC-recog-nition. In the McrB-N structure in complex with methylated DNA, the 5mC base...

  8. The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine

    Rasa Sukackaite; Saulius Grazulis; Gintautas Tamulaitis; Virginijus Siksnys
    DNA cytosine methylation is a widespread epigen-etic mark. Biological effects of DNA methylation are mediated by the proteins that preferentially bind to 5-methylcytosine (5mC) in different sequence contexts. Until now two different structural mechan-isms have been established for 5mC recognition in eukaryotes; however, it is still unknown how discrimination of the 5mC modification is achieved in prokaryotes. Here we report the crystal structure of the N-terminal DNA-binding domain (McrB-N) of the methyl-specific endonuclease McrBC from Escherichia coli. The McrB-N protein shows a novel DNA-binding fold adapted for 5mC-recog-nition. In the McrB-N structure in complex with methylated DNA, the 5mC base...

  9. SF: RUNX 3, apoptosis 0: a new gastric tumour suppressor

    S F Moss
    There is convincing evidence that Runx 3 is a new and important tumour suppressor in gastric cancer In comparison with our knowledge ofthe detailed sequence of somatic gen-etic changes occurring during colon carcinogenesis, relatively few tumour suppressors or oncogenes have been commonly implicated during the multi-stage progression to cancer in the stom-ach. Now, in a collaborative venture reminiscent of their countries ’ successful co-management of the 2002 World Cup, Li and 26 colleagues from South Korea and Japan have convincingly identified Runx 3 as a new and important tumour suppressor in gastric cancer. Runx 3 is one of three mammalian

  10. The enigmatic monotypic crab plover Dromas ardeola is closely related to pratincoles and coursers (Aves, Charadriiformes, Glareolidae)

    Sergio L. Pereira; Allan J. Baker
    The phylogenetic placement of the monotypic crab plover Dromas ardeola (Aves, Charadriiformes) remains contro-versial. Phylogenetic analysis of anatomical and behavioral traits using phenetic and cladistic methods of tree infer-ence have resulted in conflicting tree topologies, suggesting a close association of Dromas to members of different suborders and lineages within Charadriiformes. Here, we revisited the issue by applying Bayesian and parsimony methods of tree inference to 2,012 anatomical and 5,183 molecular characters to a set of 22 shorebird genera (in-cluding Turnix). Our results suggest that Bayesian analysis of anatomical characters does not resolve the phylogen-etic relationship of shorebirds with strong statistical...

  11. Protein Replacement by Receptor-Mediated Endocytosis Corrects the Sensitivity of Fanconi Anemia Group C Cells to Mitomycin C

    Hagop Youssoufian; Frank A. E. Kruyt; Xiaotong Li
    Current methods for direct gene transfer into hematopoietic cells are inefficient. Here we show that functional comple-mentation of Fanconi anemia (FA) group C cells by protein replacement can be as efficacious as by transfection with wild-type FAC cDNA. We expressed a chimeric protein (called His-ILFAC) consisting of the mature coding portion of gibbon interleukin-3 (IL-3) and full-length FAC in Escherichia coli. The purified bacterial protein is internalized by hematopoi-etic cells via IL-3 receptors. The intracellular half-life of His-ILFAC is approximately 60 minutes, which is comparable to that of the transgene-encoded FAC protein. In this cell-culture model His-ILFAC completely corrects the...

  12. [ Downloaded 12/05/2016 at 21:16:19]

    Cifali Bega Mireille; Palavras-chave Ofício; Impossível Poder; Clínica Ética
    A autora analisa a expressão "ofício impossível " tal como aparece em dois textos de Sigmund Freud: seu "Prefácio à 'Juventude desorientada ' de Aichhorn " (1925) e "Análise terminável e interminável " (1937). Em seguida, elabora uma interpretação atual à expressão freudiana, entendendo-a como piada, na associação aos três ofícios: governar, curar e educar. Aborda ainda três aspectos talvez cruciais para o futuro: o poder, a clínica e a ética.

  13. Não é só um problema de "satisfação dos usuários" : considerações sobre a participação dos usuários na avaliação da atenção básica

    Nicoli, Maria Augusta; Martino, Ardigò; Marta, Brigida Lilia; Baptista, Gabriel Calazans; Guimarães, Cristian Fabiano; Ferla, Alcindo Antônio
    Frente as transformações do novo cenário epidemiológico global, os sistemas e os serviços de saúde do Brasil e da Itália estão reorientando a lógica da assistência para produzir novas formas de cuidado, através da Atenção Primária em Saúde (a Política Nacional de Atenção Básica e a Estratégia Saúde da Família no Brasil; a implantação das Casas da Saúde na Itália), destacando a importância de colocar no centro dos processos de produção de cuidado os indivíduos e a comunidade, com os próprios valores, objetivos e trajetórias de vida. Na literatura destaca-se que para sustentar estas inovações atividades de pesquisa, avaliação e...

  14. Moda ética: Desarrollo del concepto de "consumo responsable"

    García Esteve, Alfonso
    El mundo de la moda está presente en el día a día de todos nosotros, ya que, en mayor o menor medida, todos somos consumidores de moda. Desde el diseño de una prenda, con la correspondiente elección de materiales, hasta su compra por parte del consumidor, ha sido necesario transitar por diferentes procesos como el cultivo de las materias primas, el tratado de las fibras, la confección de la prenda, el transporte de la misma y finalmente su venta en una tienda. En todos y cada uno de estos pasos, el proceso hace frente a retos sostenibles de gran envergadura....

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    Red Revistas; Científicas América Latina; El Caribe; España Y Portugal; Sistema De Información Científica; Komatsu Braga Massarollo; Maria Cristina Kurcgant; Paulina Prado Fern; Maria De Fátima; São Paulo Brasil; Comitê De; Ética Em; Pesquisa Da; Escola De; Enfermagem Da; Usp Experiência; Comité De; Ética En; Investigación De; La Escuela; De Enfermería; De La Usp
    How to cite Complete issue More information about this article Journal's homepage

  16. Dinero y naturaleza en el pensamiento escolástico medieval

    Morin, Alejandro
    El objetivo del trabajo es explorar en exponentes del pensamiento escolástico medieval algunos aspectos de la relación entre el dinero y el par Naturaleza/Creación. Se trata de un tópico que se moviliza en el contexto de la prohibición de la usura junto con otros tipos de argumento y que se ve estimulado en gran parte por el diálogo entablado con los textos de Aristóteles (Política, Ética). La condena del cobro de intereses, leído como violación del orden natural al hacer que el dinero se comporte como un ser animado dotado de virtus generativa, remite a las maneras bajomedievales de concebir...

  17. Risk management e ambiente controlo mitigadores. Negócio da banca

    Santos, Rui Mendes
    A identidade de uma Instituição é a imagem que lhe é associada pelo mercado e sociedade em geral, é o resultado do conjunto de princípios, valores e comportamentos exercidos pelos seus colaboradores e clientes, devendo aderir a elevados padrões de ética profissional e evitar situações suscetíveis de originar conflitos de interesse e fraude. Nos últimos anos várias situações têm vindo a público de posições menos claras por parte das organizações e dos seus colaboradores. Tal realidade pode ter diversas justificações, nomeadamente a atual crise económica e a crescente crise de valores existente na sociedade em geral. A necessidade de eficácia...

  18. [en] WHICH IS THE DRESS CODE? MORAL AND AESTHETIC JUDGEMENT IN THE EVANGELICAL WOMEN S DRESS

    RITA DE CÁSSIA GONÇALO ALVES
    [pt] A presente dissertação traz uma pesquisa acerca da moral evangélica que contempla o vestuário feminino como um importante elemento de distinção social. A partir da etnografia realizada em igrejas evangélicas na região metropolitana do Rio de Janeiro, procurei observar de que forma as subjetividades se manifestam nos discursos e como experiências religiosas e culturais operam nos distintos modos de vestir-se, performar-se e julgar o belo. Disso resulta que, entre o juízo de gosto e as práticas do vestir, há operações de agenciamento em que as mulheres investem na construção de uma identidade visual personalizada sem contrapor a moral evangélica, mas também evidenciando as múltiplas formas sobre como...

  19. Multi-ethnic studies in complex traits

    Jingyuan Fu; Eleonora A. M. Festen; Cisca Wijmenga
    The successes of genome-wide association (GWA) studies have mainly come from studies performed in populations of European descent. Since complex traits are characterized by marked genetic heterogeneity, the findings so far may provide an incomplete picture of the genetic architecture of complex traits. However, the recent GWA studies performed on East Asian populations now allow us to globally assess the heterogeneity of association signals between populations of European ancestry and East Asians, and the possible obstacles for multi-ethnic GWA studies. We focused on four different traits that represent a broad range of complex phenotypes, which have been studied in both...

  20. HEMATOPOIESIS Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo

    Masatsugu Ema; Tomomasa Yokomizo; Asami Wakamatsu; Tsumoru Terunuma; Masayuki Yamamoto; Satoru Takahashi
    endoglin are established markers for adult and embryonic endothelial cells (ECs). Here, we report that the expression of these EC markers is initiated in the ex-traembryonic region at the late-streak stage (nominal stage E6.75). Immunohis-tochemical analysis shows that EC mark-er–positive cells arise in a subset of Flk1 (VEGF-R2) mesodermal cells. In contrast, GATA1, a marker for primitive erythropoi-etic progenitors, is expressed in a more restricted subset of Flk1-positive cells. Using flow cytometry, we observed that the GATA1-positive cell population ex-isted as a subset of the EC marker– positive cell. Consistent with this notion, we showed with the primitive hemato-poietic colony...

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