Mostrando recursos 101 - 120 de 29,831

  1. Academic cheating and gender differences in Barcelona (Spain) Conducta deshonesta en el aula y diferencias de género en Barcelona (España)

    Mercè Clariana; Mar Badia; Ramon Cladellas; Concepción Gotzens
    El presente estudio expone las características de la conducta deshonesta en el aula, describe sus causas y examina las nefastas consecuencias que tiene para el aprendizaje. Con el fin de analizar el estado de la cuestión en nuestro país, se ha hecho una entrevista psicoeducativa y se ha aplicado un cuestionario a un total de 306 alumnos de último curso de bachillerato, último curso de universidad y último curso de Psicología en Barcelona (España). Se ha comprobado que, igual cómo ocurre en otros países, más de la mitad de los estudiantes reconocen tener el hábito de copiar, y también que...

  2. Editor in Chief: Piero Mella

    Convegno Aidea Giovani; Economia Aziendale Web; Marco Bisogno; Francesca Citro; Convegno Aidea Giovani; Marco Bisogno; Francesca Citro
    La banca etica: il modello VA.R.I.

  3. 1 RN, Bioethics expert. President of

    Juan Carlos Delgado-antolín; Sociedad Madrileña; Ética Enfermera
    essay Integrating values in the care giving activity from the professional point of view

  4. TransFind—predicting transcriptional regulators for gene sets

    Szymon M. Kiełbasa; Holger Klein; Helge G. Roider; Martin Vingron
    The analysis of putative transcription factor binding sites in promoter regions of coregulated genes allows to infer the transcription factors that underlie observed changes in gene expression. While such analyses constitute a central component of the in-silico characterization of transcriptional regulatory networks, there is still a lack of simple-to-use web servers able to combine state-of-the-art prediction methods with phylogen-etic analysis and appropriate multiple testing cor-rected statistics, which returns the results within a short time. Having these aims in mind we de-veloped TransFind, which is freely available at

  5. Idiopathic CD4 T lymphopenia without autoimmunity or granulomatous disease

    Kees C
    A girl presented during childhood with a single course of extensive chickenpox and moderate albeit recurrent pneumonia in the presence of idiopathic CD4 T lymphocytopenia (ICL). Her clinical con-dition remained stable over the past 10 years without infections, any granulo-matous disease, or autoimmunity. Immu-nophenotyping demonstrated strongly re-duced naive T and B cells with intact proliferative capacity. Antibody reactivity on in vivo immunizations was normal. T-cell receptor-V repertoire was poly-clonal with a very low content of T-cell receptor excision circles (TRECs). Kappa-deleting recombination excision circles (KRECs) were also abnormal in the B cells. Both reflect extensive in vivo prolifera-tion. Patient-derived CD34...

  6. Curso: Las virtudes del sabio estoico

    Zamora Calvo, José María
    La tesis de la implicación recíproca de las virtudes constituye un axioma central que vertebra la ética estoica. En un primer momento, parece dar cuenta del carácter inseparable de las virtudes, lo que permite explicar cómo el sabio puede llamarse con pleno derecho virtuoso en todos sus actos, aunque estos parezcan estar delimitados en cada ocasión por una virtud particular - prudencia, moderación, valentía o justicia-. Ahora bien, si partimos de la arquitectura sistemática de la filosofía estoica, la teoría de la implicación recíproca de las virtudes presenta múltiples ramificaciones. En este encuentro trataremos de analizar, mediante la selección de...

  7. Filosofia do Esporte

    No Dimensão Olímpica do dia 20 de agosto, conversamos com o professor Luiz Carlos Bombassaro, da Faculdade de Educação da UFRGS. Ele falou sobre os aspectos filosóficos do esporte, os valores e as questões éticas do olimpismo e a importância do esporte como uma ferramenta para a integração entre os povos.

  8. Los desafios éticos, jurídicos y societales de ciberespacio

    Congress Centre; Principality Of Monaco; Segundo Congreso Internacional
    Informe Final y Actas The ideas and opinions expressed in this document are those of the authors and do not necessarily reflect the views of UNESCO. Les idées et les opinions exprimées dans ce document sont celles de l’auteur et ne reflètent pas nécessairement les vues de l’UNESCO. Las ideas y opiniones expresadas en este documento son las de los autores y no reflejan necesariamente el punto de vista de la UNESCO. CII-98/CONF.401/CLD.4

  9. Type I Interferons Promote Severe Disease in a Mouse Model of Lethal Ehrlichiosis

    Humanmonocytic ehrlichiosis (HME) is caused by a tick-borne obligate intracellular pathogen of the order Rickettsiales. HME disease can range frommild to a fatal, toxic shock-like syndrome, yet the mechanisms regulating pathogenesis are not well un-derstood.We define a central role for type I interferons (alpha interferon [IFN-] and IFN-) in severe disease in a mouse model of fatal ehrlichiosis caused by Ixodes ovatus Ehrlichia (IOE). IFN- and IFN-were induced by IOE infection but not in re-sponse to a less virulent strain, Ehrlichia muris. The major sources of type I IFNs during IOE infection were plasmacytoid den-dritic cells andmonocytes. Mice lacking the...

  10. Research Article Targeted gene therapy and cell reprogramming in

    Fanconi Anemia; Yaima Torres; Juan P Trujillo; Rodolfo Murillas; Jose C Segovia; Enrique Samper; Jordi Surralles; Philip D Gregory; Michael C Holmes; Luigi Naldini; Juan A Bueren
    Gene targeting is progressively becoming a realistic therapeutic alternative in clinics. It is unknown, however, whether this tech-nology will be suitable for the treatment of DNA repair deficiency syndromes such as Fanconi anemia (FA), with defects in homology-directed DNA repair. In this study, we used zinc finger nucleases and integrase-defective lentiviral vectors to demonstrate for the first time that FANCA can be efficiently and specifically targeted into the AAVS1 safe harbor locus in fibroblasts from FA-A patients. Strikingly, up to 40 % of FA fibroblasts showed gene targeting 42 days after gene editing. Given the low number of hematopoi-etic precursors...

  11. Quartet inference from SNP data under the coalescent model

    Julia Chifman; Laura Kubatko
    Motivation: Increasing attention has been devoted to estimation of species-level phylogenetic relationships under the coalescent model. However, existing methods either use summary statistics (gene trees) to carry out estimation, ignoring an important source of variability in the estimates, or involve computationally intensive Bayesian Markov chain Monte Carlo algorithms that do not scale well to whole-genome datasets. Results: We develop a method to infer relationships among quartets of taxa under the coalescent model using techniques from algebraic statistics. Uncertainty in the estimated relationships is quantified using the nonparametric bootstrap. The performance of our method is as-sessed with simulated data. We then...

  12. The Ballistocardiogram in Juvenile Diabetes Mellitus

    E. Rakel; Thomas G. Skillman; John R. Braunstein; Me F Situdy
    Bacllisto(caidiogiraphi ( studies were made in 41 patients; with diabetes since childhood. A high incidence of abnormalities was observed. The possible diagnostic anird prognostic implications are discussed. IIE high incidence of arteriosclerosis in juveneile dial)etes is. well known. White recently reported that 88 per cent of her lar(ge series of 1072 cases had evideiice of cal-cified arteries after 29 years of diabetes.i It is evident that todav vaseular disease is the iost importallt pathologic complication of the younog dial)etic, and that coroniary athero-sclerosislplays a signtificant part in this pie-ture. The purpose of this; rel)ort is to describe the ballistocardiogralplic abnormalities...

  13. Perspective Donor cell leukemia: insight into cancer stem cells and the stem cell niche

    Catherine M. Flynn; Dan S. Kaufman
    Donor cell leukemia (DCL) is a rare compli-cation of hematopoietic cell transplanta-tion (HCT). Its incidence has been re-ported between 0.12 % and 5%, although the majority of cases are anecdotal. The mechanisms of leukemogenesis in DCL may be distinct from other types of leuke-mia. Possible causes of DCL include on-cogenic alteration or premature aging of transplanted donor cells in an immuno-suppressed person. Although many stud-ies have recently better characterized leu-kemic stem cells, it is important to also consider that both intrinsic cell factors and external signals from the hematopoi-etic microenvironment govern the devel-opmental fate of hematopoietic stem cells (HSCs). Therefore,...


    Edvaldo Luiz; Ramalli Jr. I; Wanli Hoi; Mônica Alvesii; Eduardo Melani Rochaiii
    Progress in animal experimentation ethics. A case study from a brazilian medical school and from the international medical literature1 Progresso na ética em experimentação animal. O estudo de caso de uma escola médica brasileira e da literatura médica internacional


    David Rodríguez-arias; M. ª Mar Cabezas; Facultad Filosofía; Manuales Y Antologías; Teoría General; De Bioética; Estudios De Casos; Bioética Y Feminismo; Derechos De; Los Animales; Y Experimentación Animal; Inicio De; La Vida; Y Medicina Reproductiva; Investigación Biomédica; Con Seres Humanos; Ética De; La Enfermería; Ética De; Los Trasplantes; De Órganos; Distribución De; Los Recursos Sanitarios
    BIBLID [(0213-356)10,2008,201-213] Fecha de aceptación definitiva: 30 de octubre de 2007

  16. Las competencias de emprendimiento social, COEMS: aproximación a traves de programas de formación universitaria en Iberoamérica

    Sáenz Bilbao, Nerea; López Vélez, Ana Luisa
    El auge que el emprendimiento social tiene en nuestra sociedad cada vez es mayor y muchas universidades han apostado por la educación emprendedora como parte de su misión, adquiriendo un papel de responsabilidad en la sociedad y en el proceso emprendedor, y desarrollando así una “cultura emprendedora”. No obstante, se ha constatado la necesidad de establecer un marco común sobre la formación en emprendimiento social, y las competencias que es necesario desarrollar en las personas emprendedoras sociales. Este artículo tiene como objetivo reflexionar sobre dichas competencias, a través de una revisión de lo planteado en la literatura. A su vez,...


    Christel Moog-lutz; David A. Calderwood; Pierre G. Lutz
    The ordered series of proliferation and differentiation from hematopoietic pro-genitor cells is disrupted in leukemia, resulting in arrest of differentiation at immature proliferative stages. Character-izing the molecular basis of hematopoi-etic differentiation is therefore important for understanding and treating disease. Retinoic acid induces expression of ankyrin repeat-containing protein with a suppressor of cytokine signaling box 2 (ASB2) in acute promyelocytic leukemia cells, and ASB2 expression inhibits growth and promotes commitment, reca-pitulating an early step critical for differen-tiation. ASB2 is the specificity subunit of an E3 ubiquitin ligase complex and is proposed to exert its effects by regulating the turnover of specific...

  18. $rec.titulo

    N-linked sialyated sugar receptors support haematopoietic cell-osteoblast adhesions In adults the bone marrow is the sole microenvironment that supports all activities of normal haematopoiesis. Haematopoi-etic stem cells (HSCs) home to bone marrow during devel-opment and transplantation where pluripotency is maintained and maturity is facilitated (Nelissen et al, 2000). Both of these activities are likely to require different growth factors and cellular contexts. Bone marrow stromal cells are comprised of several different cellular populations including fibroblasts, endothelial and reticular cells, adipocytes and osteoblasts (OB) which serve as a rich source of growth factors (Eaves et al,

  19. Preparation of 4‘-Amino Hexopyranose Nucleosides from Keto Nucleosides. An Approach to Amino Nucleoside Antibiotics

    Jean Herscovici; Marie-jose Egron; Kostas Antonakis
    Amino hexopyranose nucleosides were prepared by treatment of the keto group with hydroxylamine hydrochloride followed by acetylation of the resulting oxime. Among other reagents, sodium borohydride-nickel chloride or sodium borohydride-molybdenum(vi) oxide were found to be excellent reductive systems for the facile synthesis of amino hexopyranose nucleosides. The 4’-amino hexopyranose skeleton is found in several biologically active naturally occurring nucleosides including gougerotin and blasticidin ‘ 9 ’ which are of great interest due to their pronounced antibiotic and antitumoral activities. Synth-etic approaches to these nucleosides have been reported to occur either by condensation of amino sugars with heterocyclic bases 3*4 or...


    James P. Walsh; Michael L. Tushman; John R. Kimberly; Bill Starbuck; Susan Ashford; James P. Walsh
    This article offers a lively and spirited debate on the pros and cons of relating research to practice. The authors ’ goal is to illuminate fundamental issues in the debate in detail, consider a variety of prescriptions, and then come to a mindful conclusion about a course of action. The article begins with a point–counterpoint debate to make sure that scholars fully understand the issues in play. Mike Tushman starts off by arguing for an emic approach. He believes that scholars are most effective when they closely work with management and organizations. John Kimberly counters with an etic perspective. He...

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