Mostrando recursos 101 - 120 de 26,109

  1. El concepte de racionalitat en tecnologia educativa

    Sarramona, Jaume
    L'anàlisi epistemològic de la tecnologia educativa ha de fer-se sota la doble perspectiva de la naturalesa del coneixement científic i del fenomen educatiu. Tal anàlisi resulta especialment necessari en aquests moments, quan estan en profunda revisió dels principis que van fonamentar la tecnologia educativa en els seus començaments. En aquest treball es presenten inicialment les set notes que, segons el parer de l'autor, caracteritzen la tecnologia educativa actual: 1) racionalitat, 2) sistematisme, 3) planificació, 4) claredat de metes, 5) control, 6) eficàcia i 7) optimització. No obstant això, només es desenvolupa la primera d'elles, la racionalitat, que és la que...

  2. La educación mundialista

    Fontan Jubero, Pere
    En l'intent d'educar els nens en una consciència de ciutadania mundial s'ensopega amb l'obstacle de la sobirania il·limitada que s'atribueixen alguns estats. Partint de la idea d'un federalisme mundial que realitzaria la unitat planetària, i basant-se en una idea ètica de justícia universal, s'arriba a un programa pedagògic d'educació mundialista, que és una educació integral propugnada per l'Institut d'Estudis Mundialistes.

  3. Mejora de la Calidad en la Resolución de Casos por el Comité de Ética (CEA) del Sector de Teruel con la aplicación de estrategias narrativas

    Gómez Cadenas, Concha; Herrero Vicente, Jesús; Pereyra Grustán, Lorena; García Sanz, Montse; Agudo Rodrigo, Marta C.; Herrando Vicente, Victoria; Carod Benedico, Etel
    We will try to answer the question: Why narrative tool is important and useful to deliberate on the CEA? In our CEA, we used the Deliberative Method of Professor Diego Gracia (MDDG), and in this method the narrative appears as a essential requisite. When we have a problem and we seek advice, first we need to be understood, and to do that, we tell a story, we narrate in a natural way the facts, and we hope you will understand that there are values behind them. It happens that often we are not able to see the values, (ours and many more...

  4. La diversidad cultural oaxaqueña a la luz de la ética ambiental

    Filgueiras Nodar, José María
    This article attempts to relate some aspects of the world views of different native peoples of Oaxaca State (Mexico) with certain interests of contemporary environmental ethics, from the perspectives of environmental pragmatism and comparative environmental ethics. It will demonstrate that two elements displayed in the worldviews of several Oaxacan ethnicities are relevant for environmental ethics, these being the existence of deities linked to environmental protection and ideas about the place that human beings occupy in the world.

  5. Contribución de los comités de bioética al mejoramiento ético en las prácticas de la salud:

    Gomes, Doris; Siurana, Juan Carlos
    Different approaches about bioethics committees from the experiences of Brazil and Spain lead to the following question: what contribution has given that new reality of committees practical functioning to improve health practices? Brazil and Spain have similarities with the legal frameworks that established health systems since both countries follow the social security model. Analyzing experiences broaden the understanding of their inferences on health practices and human improvement, while new needs.

  6. La deliberación en los comités de ética asistencias: Phrónesis, no techne

    Pérez Zafrilla, Pedro Jesús
    Los comités de ética asistencial constituyen ámbitos deliberativos en los que se pretende aportar soluciones a los problemas de carácter ético que surgen en el mundo sanitario. No obstante, en ellos suele ponerse el acento en el “método” para encontrar una respuesta a los problemas planteados. Se tiende a pensar así que el “método deliberativo” es más un arte que como un ejemplo típico de la prudencia. En esta comunicación pretendo rebatir esta idea.

  7. Imagem e criação de si a partir da arte : possibilidades ético-estéticas em educação infantil

    Idzi, Taila Suian
    A presente investigação parte do questionamento a respeito das potências dos encontros entre arte e infância para pensar o si mesmo. Para tanto, temos com horizonte teórico os últimos estudos de Michel Foucault, nos quais o autor se debruça sobre a constituição do sujeito na Antiguidade Clássica. É, portanto, a partir do estudo das técnicas de si greco-romanas, precisamente aquelas ligadas à escrita de si, que se busca pensar as possíveis formas de relação consigo hoje, por meio das relações entre arte e infância. Mais precisamente, o objetivo desta pesquisa é discutir de que maneiras é possível, hoje, falar, pensar,...

  8. The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine

    Rasa Sukackaite; Saulius Grazulis; Gintautas Tamulaitis; Virginijus Siksnys
    DNA cytosine methylation is a widespread epigen-etic mark. Biological effects of DNA methylation are mediated by the proteins that preferentially bind to 5-methylcytosine (5mC) in different sequence contexts. Until now two different structural mechan-isms have been established for 5mC recognition in eukaryotes; however, it is still unknown how discrimination of the 5mC modification is achieved in prokaryotes. Here we report the crystal structure of the N-terminal DNA-binding domain (McrB-N) of the methyl-specific endonuclease McrBC from Escherichia coli. The McrB-N protein shows a novel DNA-binding fold adapted for 5mC-recog-nition. In the McrB-N structure in complex with methylated DNA, the 5mC base...

  9. RESEARCH ARTICLE Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in

    The Bone Marrow; Kentaro Yoshioka; Akihisa Oda; Chihiro Notsu; Takafumi Ohtsuka; Yasuhiro Kawai; Sadafumi Suzuki; Takuro Nakamura; Yo Mabuchi; Yumi Matsuzaki; Ryo Goitsuka
    Prep1, a TALE-family homeodomain transcription factor, has been demonstrated to play a critical role in embryonic hematopoiesis, as its insufficiency caused late embryonic lethality associated with defective hematopoiesis and angiogenesis. In the present study, we gener-ated hematopoietic- and endothelial cell-specific Prep1-deficient mice and demonstrated that expression of Prep1 in the hematopoietic cell compartment is not essential for either embryonic or adult hematopoiesis, although its absence causes significant hematopoietic abnormalities in the adult bone marrow. Loss of Prep1 promotes cell cycling of hematopoi-etic stem/progenitor cells (HSPC), leading to the expansion of the HSPC pool. Prep1 deficiency also results in the accumulation...

  10. CeLL CyCLe News & Views


    in hybrid cells formed by artificial cell fusion or sexual hybridization, 2 different parental genomes are combined within one cell. intergenomic parental conflicts may be a consequence of such a novel genomic con-stitution and result in genomic and epigen-etic reorganization of the genomes, and even somatic elimination of some or all chromo-somes from one parental species may occur. several explanations have been proposed to account for chromosome elimination, such as difference in timing of essential mitotic processes and parent-specific inactivation of centromeres. However, the mechanism under-lying the elimination of uniparental chromo-

  11. Contents


    Abstract. Gastric cancer (GC) is the fourth most commonly diagnosed type of cancer worldwide and has the second highest mortality rate of all cancer types. Classical genetics alone does not fully explain how GC occurs; however, epigenetics provides a partial explanation with regard to the cause of cancer. DNA methylation, the best-known type of epigen-etic marker, represses the expression of tumor-suppressor genes and is involved in the pathogenesis of various types of human cancer, including GC. Micro (mi)RNAs are critical in the initiation, progression, metastasis and invasion of GC through gene regulation. The dysregulation of miRNAs is widely recognized as...

  12. vegetarians, and 2246 vegans1–4

    Timothy J Key; Francesca L Crowe; Kathryn E Bradbury; Julie A Schmidt; Ruth C Travis
    Background: Vegetarian diets might affect the risk of cancer. Objective: The objective was to describe cancer incidence in veg-etarians and nonvegetarians in a large sample in the United King-dom. Design: This was a pooled analysis of 2 prospective studies includ-ing 61,647 British men and women comprising 32,491 meat eaters, 8612 fish eaters, and 20,544 vegetarians (including 2246 vegans). Cancer incidence was followed through nationwide cancer regis-tries. Cancer risk by vegetarian status was estimated by using mul-tivariate Cox proportional hazards models. Results: After an average follow-up of 14.9 y, there were 4998 incident cancers: 3275 in meat eaters (10.1%), 520 in...

  13. METHODOLOGY ARTICLE Bulk segregant RNA-seq re s s


    Performance is related to the subtle variation in gene ex-pression and this relationship differs among individuals [1]. In well-defined families, the first level of variation comes from genetic segregation and recombination of chromosomes. As a result of segregation and chromo-somal recombination, each individual has different gen-etic makeup. Upon a given genetic background, genetic potential carried on DNA can only be realized when the genes are expressed. At the whole genome level, expression of each gene is affected by its genetic regulatory elem-ent as well as trans-acting factors including the impact of environment. A composite of genes, transcriptional regulation, post-transcriptional modification...

  14. RESEARCH ARTICLE Mitochondrial Reactive Oxygen Species Regulate Adipocyte Differentiation of Mesenchymal Stem Cells in Hematopoietic Stress Induced by Arabinosylcytosine

    Yao Zhang; Wenyi Lu; Kaiyan Liu
    Objective The increase in adipocytes induced by chemotherapeutic drugs may play a negative role in hematopoietic recovery. However, the mechanism underlying adipocyte differentiation of mesenchymal stem cells (MSCs) in hematopoietic stress is still unknown. Hence, the in-volvement of reactive oxygen species (ROS) in adipocyte differentiation under hematopoi-etic stress was investigated in vitro and in vivo. Methods The roles of cellular ROS in adipogenesis were investigated in vivo through an adipocyte hyperplasia marrow model under hematopoietic stress induced by arabinosylcytosine (Ara-C) and in vitro via adipocyte differentiation of human MSCs. ROS levels were detected using the CM-H2DCFDA probe and Mito-SOX dye....

  15. Redefinindo o concepto de río para un novo marco socio-ecolóxico

    García García, Jesús Horacio
    No país dos mil ríos a sociedade galega ten a obriga de protexer, conservar e valorar os sistemas fluviais. O dano infrinxido durante décadas aos nosos ríos é, por desgraza, rico e diverso, polo que temos o deber ético de arranxar o dano feito. Desde algúns países cunha maior sensibilidade ecolóxica estanse poñendo en valor interesantes iniciativas que invitan a mudar o xeito de xestionar os nosos espazos fluviais. Pero é tamén preciso un cambio de paradigma como sociedade que axude a preservar estes espazos naturais tan prezados que son os ríos. Este cambio de paradigma afecta desde a propia...

  16. Etica y democracia

    Mejía Velásquez, Ignacio
    El fondo del tema que me propongo plantear. Es el de que la democracia que estamos llevando no es auténtica: lo resumiría en esta especie de paradoja, que nace de la Nueva Constitución (del nuevo texto-hablar de la Nueva Constitución es un poco pedante porque no fue nueva pero sí hay un nuevo texto que repite en gran parte lo anterior con muchísimas mayores palabras y menor propiedad en general), que dice que Colombia es una nueva República democrática, lo que ya envolvería un pleonasmo si no fuera porque me parece que el subconsciente traicionó a los constituyentes y que...

  17. Valor de la reflexión moral

    Múnera Vélez, Darío
    Agradezco vivamente al señor Decano y a los organizadores de este Foro de Etica, la preocupación por ofrecer tan interesante y urgente tema de reflexión: "Conceptos éticos en la Nueva Constitución". La comunidad académica, profe sores y alumnos encontrarán aquí un sano y refrescante alimento cultural, cuya fuerza debe estar en el compromiso moral de la conducta personal y pública en el ejercicio de la profesión del derecho. Deseo instalar este Foro haciendo una breve consideración sobre el porqué de la reflexión moral en sí misma y en el claustro de la Universidad. (…)

  18. Consideraciones éticas para los jueces y aspirantes a la judicatura

    Gómez Gómez, Fernando
    Todo lo que voy a deciros lo habéis escuchado y, en consecuencia, nada nuevo hay en mis palabras como en pocas cosas lo hay. Sólo que, en veces, la actualización, la manera de enfatizar y el método persuasivo pueden suministrar algún revestimiento, pero "Nihil novum sub sole", nada nuevo hay bajo el sol. Se encaminará mi intervención, por tanto, a refrescaros algunas ideas sobre la Etica, a recordaros la sublimidad de la justicia y, por fin, cuál es el camino obligado de todos nosotros los jueces en la realización de la justicia, para que de manera obvia y clara se nos...

  19. Lealtad como supremo imperativo ético del proceso penal

    Vargas, Alvaro
    La vida, esta vida parva que escribiera bellamente Porfirio Barba Jacob, no nos da sus mieles sino con cierto ritmo y en cierta proporción nos otorga, empero, a los simples mortales como yo, gozos espirituales tan exquisitos como, por ejemplo, éste que me brinda la posibilidad de conversar con tantos y tan queridos amigos colegas y discípulos en tomo a los problemas siempre interesantes de las relaciones entre la ética y el proceso, sobre todo el proceso penal. (…)

  20. Un abogado para la democracia

    Velásquez Velásquez, Fernando
    Conferencia pronunciada con motivo del Seminario Nacional de Etica organizado por la Facultad de Derecho de la U.P.B.

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