Mostrando recursos 21 - 40 de 26,094

  1. Ética y buenas prácticas en publicaciones

    EAN, Universidad

  2. CoPAP: Coevolution of Presence–Absence Patterns

    Ofir Cohen; Haim Ashkenazy; Eli Levy Karin; David Burstein; Tal Pupko
    Evolutionary analysis of phyletic patterns (phylogen-etic profiles) is widely used in biology, representing presence or absence of characters such as genes, restriction sites, introns, indels and methylation sites. The phyletic pattern observed in extant genomes is the result of ancestral gain and loss events along the phylogenetic tree. Here we present CoPAP (coevolution of presence–absence patterns), a user-friendly web server, which performs accurate inference of coevolving charac-ters as manifested by co-occurring gains and losses. CoPAP uses state-of-the-art probabilistic methodologies to infer coevolution and allows for advanced network analysis and visualization. We developed a platform for comparing different algorithms that detect...

  3. W


    l f consequences for sexual selection, sperm competition, and of multiple paternity? Loope et al. BMC Evolutionary Biology (2014) 14:2625 DOI 10.1186/s12862-014-0277-xmultiple paternity results in a colony with diverse gen-etic defenses against coevolving natural enemies, thus USA Full list of author information is available at the end of the articlethe evolution of male reproductive strategies [2,3]. But the evolution of multiple mating and multiple paternity itself is an evolutionary puzzle. It has arisen several times in the social Hymenoptera, including in a handful of ant genera, the honey bees (Apis spp.), and some vespine Many hypotheses have been proposed to...

  4. © 2012 Landes Bioscience. Do not distribute.

    Mir Farshid Alemdehy; Stefan J. Erkel
    MicroRNAs (miRNAs) belong to an abundant class of highly con-served small (22nt) non-coding RNAs. MiRNA profiling studies indicate that their expression is highly cell type-depen-dent. DICER1 is an essential RNase III endoribonuclease for miRNA process-ing. Hematopoietic cell type- and devel-opmental stage-specific Dicer1 deletion models show that miRNAs are essential regulators of cellular survival, differ-entiation and function. For instance, miRNA deficiency in hematopoietic stem cells and progenitors of different origins results in decreased cell survival, dra-matic developmental aberrations or dys-functions in mice. We recently found that homozygous Dicer1 deletion in myeloid-committed progenitors results in an aber-rant expression of stem cell genes...

  5. A Comprehensive Study on the Etiolo Cochlear Implantation With Sp Genetic Epidemio

    Ymaiko Miyagawa; Yshin-ya Nishio; Otology Neurotology
    treatmen hearing etiology tation, an Methods cochlear (EAS) in onset: 92 Invader assay followed by the targeted exon-sequencing of 63 deafness genes using Massiv (MPS) was applied. For pre imaging ination w Results: mutation and in 36 in the kin groups. A ochle ations clusi or ca essin expre itory etic orma causative deafness genes in patients receiving cochlear implan-egion inside/ onsible gene ssen hlea logy—GJB2—LOXHD1—MYO7A—MYO6—MYO15A— t-gen l Neu Genet profound cochlear (EAS) o ‘‘intraco comes (1 region in sible ge auditory performance after re with specificdeafnessgenemutations indicates thatgenetic ing w ell a ause s, th tinue gene h no...

  6. RESEARCH Association of COL4A1 gen a


    ura ce etic basis of CAD has gained considerable interest [1]; basement membrane (BM) and is expressed at all tissues Adi et al. Lipids in Health and Disease 2013, 12:153 http://www.lipidworld.com/content/12/1/153chemia. Type IV collagen, a major component of vascular2Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, People’s Republic of Chinaheritable factors accounted for 40%-60 % in occurrence and development of CAD [2]. Genome- wide association studies (GWAS) some large-scale association analysis have identified many common, uncommon and functional vari-ants for CAD [3,4]. Collagens are a group of proteins characterized by a unique sequence whose every third amino acid is...

  7. 2Mestre pelo Programa de Pós-Graduação em Ciências da Saúde-Pediatria da Universidade Federal do Rio Grande do Sul (UFRGS); Médico do Serviço de Medicina Fetal do Hospital Materno Infantil Presidente Vargas, Porto

    Rev Paul Pediatr; Daniela Denardin; Jorge Alberto; B. Telles; Rosilene Da Silveira Betat; Paulo Renato; K. Fell; André Campos Da Cunha; Luciano Vieira Targa; Paulo Ricardo; G. Zen; Rafael Fabiano; M. Rosa; Instituição Hospital; Materno Infantil; Presidente Vargas Tomoclínica; Alegre Rs Brasil; Porto Alegre; Geneticista Clínico; Hospital Materno; Infantil Presidente; Vargas Professor
    Imperfect twinning: a clinical and ethical dilemma Gemelaridade imperfeita: um dilema clínico e ético Gemelizaciónimperfecta: un dilema clínico y ético

  8. «Spinoza, una cartografía de la ética», o el periplo desde y hacia una infinitud por explorar

    Álvarez Montero, Daniel

  9. Molécula HLA-G y su importancia en la inmunorregulación de la unidad feto-materna. Aplicaciones en inmunoterapia celular

    Macedo Pereira, Jacqueline
    OBJETIVOS El objetivo principal de esta tesis doctoral consiste en determinar la presencia de la proteína HLA-G en la superficie celular de células madre CD34/CD133, células dendríticas mieloides y plasmacitoides, células dendríticas derivadas de células CD34/CD133 y derivadas de monocitos de sangre de cordón umbilical y sangre periférica materna, por técnicas de citometría de flujo y la expresión de la proteína HLA-G soluble en plasma de sangre de cordón umbilical por técnicas de ELISA. MATERIALES Y METODOS Se obtuvo un total de 35 unidades de sangre de cordón umbilical y 35 muestras de sangre periférica de gestantes a término que...

  10. $rec.titulo


    Abstract. Chronic myeloid leukemia (CML) is a hematopoi-etic stem cell disease caused by the oncoprotein BCR-ABL, which exhibits a constitutive tyrosine kinase activity. Imatinib mesylate (IM), an inhibitor of the tyrosine kinase activity of BCR-ABL, has been used as a first-line therapy for CML. However, IM is less effective in the accelerated phase and blastic phases of CML and certain patients develop IM resistance due to the mutation and amplification of the BCR-ABL gene. Fangchinoline, an important chemical constituent from the dried roots of Stephaniae tetrandrae S. Moore, exhibits significant antitumor activity in various types of cancers, including breast, prostate...

  11. RESEARCH ARTICLE Decision tree analysis of g r


    can also involve deterioration of language, visuospatial and/or executive functioning abilities. As the world’s ity of AD therapies given to individuals at highest gen-etic risk for AD but who are still cognitively healthy [1]. Yokoyama et al. BMC Neurology (2015) 15:47

  12. RESEARCH ARTICLE Contrasting patterns of ge


    pu ati, c es ural outcrops of heavy metal-rich rock or mining activ- homeostasis networks [9]. In the past 50 years, genetic Ye et al. BMC Evolutionary Biology 2012, 12:84 http://www.biomedcentral.com/1471-2148/12/84heavy metal contaminated area. Therefore, a reductionUniversity, Guangzhou 510275, People's Republic of China Full list of author information is available at the end of the articleities [1-3]. Metallophytes refer to plant species that have developed metabolic mechanisms to resist, tolerate, or even thrive on toxic metalliferous soils [4-6]. Populations of metallophytes growing in metalliferous soils are often genetically distinct from those living in nearby non-metalliferous soils [7]. Metalliferous habitats are...

  13. Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

    Andrew E. Teschendorff; James West; Stephan Beck
    It is now well established that the genomic landscape of DNA methylation (DNAm) gets altered as a function of age, a process we here call ‘epigenetic drift’. The biological, functional, clinical and evolutionary significance of this epigenetic drift, however, remains unclear. We here provide a brief review of epigenetic drift, focusing on the potential implications for ageing, stem cell biology and disease risk prediction. It has been demonstrated that epigenetic drift affects most of the genome, suggesting a global deregulation of DNAm patterns with age. A com-ponent of this drift is tissue-specific, allowing remarkably accurate age-predictive models to be constructed....

  14. Background

    Mitsuyoshi Urashima; Takakuni Kato; Hiroshi Moriyama
    Progress in genomics has led to the identification of oncogenes, and genetic mutations associated with car-cinogenesis have been reported for many carcinomas. Furthermore, an increase in the gene copy number due to focal amplification or chromosomal polysomy is another major mechanism of oncogene activation [1]. In addition to progress in the understanding of signaling pathways, there have been pharmaceutical advances with regard to the development of drugs that target proteins in membrane receptors and the downstream signals associated with carcinogenesis. Various trials have been performed to assess individualized drugs for the treat-ment of cancer that target the patients ’ individual...

  15. Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci

    Satish Sati; Sourav Ghosh; Vaibhav Jain; Vinod Scaria; Shantanu Sengupta
    A major fraction of the transcriptome of higher or-ganisms comprised an extensive repertoire of long non-coding RNA (lncRNA) which express in a cell type and development stage-specific manner. While lncRNAs are a proven component of epigen-etic gene expression modulation, epigenetic regula-tion of lncRNA itself remains poorly understood. Here we have analysed pan-genomic DNA methyla-tion and histone modification marks (H3K4me3, H3K9me3, H3K27me3 and H3K36me3) associated with transcription start site (TSS) of lncRNA in four different cell types and three different tissue types representing various cellular stages. We observe that histone marks associated with active transcrip-tion H3K4me3 and H3K36me3 along with the...

  16. PRIMARY RESEARCH SIRT1 affects DNA methyla e r


    Background A notable feature of the age-related drift in DNA methyla-etic stem cells support the nges in DNA cess. For ex-programming Wakeling et al. Human Genomics (2015) 9:14 DOI 10.1186/s40246-015-0036-0span in each successive generation, provides a compellingUK Full list of author information is available at the end of the articlein the process of gamete formation, which must reverse the ageing clock to prevent progressively shortened life-

  17. RESEARCH d e o


    Lay summary breed. Dog leukocyte antigen (DLA) class II genes code LA genes can oimmune dis-(CTLA4) is a r the immune mune system Threlfall et al. Canine Genetics and Epidemiology (2015) 2:8 DOI 10.1186/s40575-015-0020-yeases in humans and dogs, especially diseases of the immune system. The aim of this study was to investigate Mymms, Hatfield AL9 7TA, Hertfordshire, UK Full list of author information is available at the end of the articlecan become relatively hyperactive. Alterations in the gen-etic code for this molecule are associated with several dis- * Correspondence:

  18. JOURNAL OF MEDICAL


    na tif nervous system, heart and lungs [1]. TSC arises from gen-etic alterations in one of two genes: TSC1 (encoding

  19. Departamento de Medicina Legal, Ética

    Rev Saúde Pública; São Paulo; São Paulo; São Paulo; São Paulo; Lucio Garcia De Oliveira; São Paulo Sp
    Occupational conditions and the risk of the use of amphetamines by truck drivers

  20. Agricultores familiares da região sul da amazônia brasileira: uma contribuição à crise ecológica global

    Abreu, Lucimar S. de; Santos, Amaury; Watanabe, Maria Aico
    Poucos estudos têm analisado o papel da população amazônica para a conservação ecológica da biodiversidade e para a redução dos efeitos da crise ecológica global. Esse estudo aborda experiências com Sistemas Agroflorestais (SAFs) desenvolvida pela Associação de Produtores Alternativos (APA), em Ouro Preto do Oeste - RO. O objetivo foi o de verificar se é possível conciliar a conservação ambiental com o desenvolvimento da agricultura familiar no sul da Amazônia. A hipótese é que a agrobiodiversidade associada aos sistemas agroflorestais contribui para a minimização da crise ambiental global. Essa afirmação se contrapõe ao velho diagnóstico de culpar os agricultores menos...

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