Documentos: 
1. (�)
Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis.
- Ruperto, N; Brunner, HI; Quartier, P; Constantin, T; Wulffraat, N; Horneff, G; Brik, R; McCann, L; Kasapcopur, O; Rutkowska-Sak, L; Schneider, R; Berkun, Y; Calvo, I; Erguven, M; Goffin, L; Hofer, M; Kallinich, T; Oliveira, SK; Uziel, Y; Viola, S; Nistala, K; Wouters, C; Cimaz, R; Ferrandiz, MA; Flato, B; Gamir, ML; Kone-Paut, I; Grom, A; Magnusson, B; Ozen, S; Sztajnbok, F; Lheritier, K; Abrams, K; Kim, D; Martini, A; Lovell, DJ; PRINTO,; PRCSG,
Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human, anti-interleukin-1β - 21-may-2013
2. (�)
Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile
- Nagata, S; McKenzie, C; Pender, SLF; Bajaj-Elliott, M; Fairclough, PD; Walker-Smith, JA; Monteleone, G; MacDonald, TT
Animal studies have demonstrated that feeding Ags induces regulatory (Th2, Th3) cells in Peyer's pat ... - 09-may-2013
3. (�)
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease
- Heuschkel, RB; MacDonald, TT; Monteleone, G; Bajaj-Elliott, M; Smith, JAW; Pender, SLF
Background-Degradation of the extracellular matrix and ulceration of the mucosa are major features o ... - 09-may-2013
4. (�)
Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis
- Taylor, PC; Peters, AM; Paleolog, E; Chapman, PT; Elliott, MJ; McCloskey, R; Feldmann, M; Maini, RN
OBJECTIVE: To verify the hypothesis that in rheumatoid arthritis (RA), tumor necrosis factor alpha (TNFalpha) plays a critical role in regulating leukocyte trafficking and chemokine levels. METHODS - 08-may-2013
5. (�)
A population pharmacokinetic-pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis
- Mould, DR; Davis, CB; Minthorn, EA; Kwok, DC; Elliott, MJ; Luggen, ME; Totoritis, MC
rheumatoid arthritis in which T cell activation orchestrates inflammation and tissue damage. In this - 08-may-2013
6. (�)
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
- Maini, RN; Breedveld, FC; Kalden, JR; Smolen, JS; Davis, D; Macfarlane, JD; Antoni, C; Leeb, B; Elliott, MJ; Woody, JN; Schaible, TF; Feldmann, M
, Centocor, Malvern, PA) given alone or in combination with low-dose methotrexate (MTX) in rheumatoid arthritis (RA) patients. METHODS: In a 26-week, double-blind, placebo-controlled, multicenter trial - 08-may-2013
7. (�)
Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis
- Feldmann, M; Elliott, MJ; Woody, JN; Maini, RN
- 08-may-2013
8. (�)
Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade
- Davis, D; Charles, PJ; Potter, A; Feldmann, M; Maini, RN; Elliott, MJ
Anaemia of chronic disease (ACD) is a common feature of active rheumatoid arthritis (RA). Inflammatory cytokines, particularly tumour necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1) and - 08-may-2013
9. (�)
Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis
- Paleolog, EM; Hunt, M; Elliott, MJ; Feldmann, M; Maini, RN; Woody, JN
OBJECTIVE: To assess whether monoclonal antibody to tumor necrosis factor alpha (TNF alpha) reduces endothelial activation in rheumatoid arthritis (RA). METHODS: Levels of serum E-selectin - 08-may-2013
10. (�)
Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action
- Feldmann, M; Brennan, FM; Williams, RO; Elliott, MJ; Maini, RN
alpha antibody in rheumatoid arthritis (RA) in humans. The mechanism of action of anti-TNF alpha will ... such as rheumatoid joints. A very wide range of cytokines were detected, mostly with proinflammatory - 08-may-2013 | |
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