http://biblioteca.universia.net/verColeccion.do?id=3397 Mostrando recursos 1 - 20 de 101 es http://biblioteca.universia.net/img/logotipo.jpg http://biblioteca.universia.net/ http://biblioteca.universia.net/ficha.do?id=6181008 Fall, Abbie M; Johnsen, Russell; Honeyman, Kaite; Iversen, Pat; Fletcher, Susan; Wilton, Stephen D http://biblioteca.universia.net/ficha.do?id=6961038 The rapid degradation of ribonucleic acids (RNA) by ubiquitous ribonucleases limits the efficacy of new therapies based on RNA molecules. Therefore, our aim was to characterize the natural ribonuclease activities on the skin and in blood plasma i.e. at sites where many drugs in development are applied. On the skin surfaces of Homo sapiens and Mus musculus we observed dominant pyrimidine-specific ribonuclease activity. This activity is not prevented by a cap structure at the 5'-end of messenge... Probst, Jochen; Brechtel, Sonja; Scheel, Birgit; Hoerr, Ingmar; Jung, Günther; Rammensee, Hans-Georg; Pascolo, Steve http://biblioteca.universia.net/ficha.do?id=17974162 Garrett, Deiadra J; Cohen, J Craig; Larson, Janet E http://biblioteca.universia.net/ficha.do?id=17987908 Zhong, Shumei; Sun, Shihua; Teng, Ba-Bie http://biblioteca.universia.net/ficha.do?id=18013519 Zhang, Bing; Metharom, Pat; Jullie, Howard; Ellem, Kay AO; Cleghorn, Geoff; West, Malcolm J; Wei, Ming Q http://biblioteca.universia.net/ficha.do?id=18013556 Söling, Ariane; Theiß, Christian; Jungmichel, Stephanie; Rainov, Nikolai G http://biblioteca.universia.net/ficha.do?id=18013557 Zhang, Weidong; Singam, Rajeswari; Hellermann, Gary; Kong, Xiaoyuan; Juan, Homero San; Lockey, Richard F; Wu, Shuen-Ju; Porter, Kevin; Mohapatra, Shyam S http://biblioteca.universia.net/ficha.do?id=18014127 Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer is the preferred outcome. The most important advantage that retroviral vectors offer is their ability to transform their single stranded RNA genome into a double stranded DNA molecule that stably integrates into the target cell genome. This means that retroviral vectors can be used to permanently... Anson, Donald S http://biblioteca.universia.net/ficha.do?id=18014907 Harms, Jerome S; Eakle, Kurt A; Kuo, Lillian S; Bremel, Robert D; Splitter, Gary A http://biblioteca.universia.net/ficha.do?id=18014908 Modulation of the immune system by genetically modified immunological effector cells is of potential therapeutic value in the treatment of malignancies. Interleukin-2 (IL-2) is a crucial cytokine which induces potent antitumor response. Cytokine-induced killer cells (CIK) have been described as highly efficient cytotoxic effector cells capable of lysing tumor cell targets and are capable of recognizing these cells in a non-MHC restricted fashion. Dendritic cells (DC) are the major antigen pre... Nagaraj, Srinivas; Ziske, Carsten; Schmidt-Wolf, Ingo GH http://biblioteca.universia.net/ficha.do?id=18015812 McKee, Hayley J; T'sao, Patricia Y; Vera, Maria; Fortes, Puri; Strayer, David S http://biblioteca.universia.net/ficha.do?id=18017688 The rapid progress in the field of genomics is increasing our knowledge of multi-gene diseases. However, any realistic hope of gene therapy treatment for those diseases needs first to address the problem of co-ordinately co-expressing several transgenes. Currently, the use of internal ribosomal entry sites (IRESs) is the strategy chosen by many researchers to ensure co-expression. The large sizes of the IRESs (~0.5 kb), and the difficulties of ensuring a well-balanced co-expression, have prom... de Felipe, Pablo http://biblioteca.universia.net/ficha.do?id=18019878 The establishment of efficient gene delivery to target human tissue is a major obstacle for transition of gene therapy from the pre-clinical phases to the clinic. The poor long-term patency rates for coronary artery bypass grafting (CABG) is a major clinical problem that lacks an effective and proven pharmacological intervention. Late vein graft failure occurs due to neointima formation and accelerated atherosclerosis. Since CABG allows a clinical window of opportunity to genetically modify v... Work, Lorraine M; Reynolds, Paul N; Baker, Andrew H http://biblioteca.universia.net/ficha.do?id=18021664 Ebert, Oliver; Wilbert, Dorothee; Buttgereit, Peter; Ziske, Carsten; Flieger, Dimitri; Schmidt-Wolf, Ingo GH http://biblioteca.universia.net/ficha.do?id=18025457 Chapel, Alain; Deas, Olivier; Bensidhoum, Morad; François, Sabine; Mouiseddine, Moubarak; Poncet, Pascal; Dürrbach, Antoine; Aigueperse, Jocelyne; Gourmelon, Patrick; Gorin, Norbert C; Hirsch, François; Thierry, Dominique http://biblioteca.universia.net/ficha.do?id=18033606 The complexity of parasitic infections requires novel approaches to vaccine design. The versatility of DNA vaccination provides new perspectives. This review discusses the use of prime-boost immunizations, genetic adjuvants, multivalent vaccines and codon optimization for optimal DNA vaccine design against parasites. Ivory, Catherine; Chadee, Kris http://biblioteca.universia.net/ficha.do?id=18036913 We have constructed and evaluated the utility of a helper-dependent virus vector system that is derived from Human Cytomegalovirus (HCMV). This vector is based on the herpes simplex virus (HSV) amplicon system and contains the HCMV orthologs of the two cis-acting functions required for replication and packaging of HSV genomes, the complex HCMV viral DNA replication origin (oriLyt), and the cleavage packaging signal (the a sequence). The HCMV amplicon vector replicated independently and was pa... Mahmood, Kutubuddin; Prichard, Mark N; Duke, Gregory M; Kemble, George W; Spaete, Richard R http://biblioteca.universia.net/ficha.do?id=18076543 Iversen, Nina; Birkenes, Baard; Torsdalen, Kari; Djurovic, Srdjan http://biblioteca.universia.net/ficha.do?id=18076842 Perkins, Stuart D; Flick-Smith, Helen C; Garmory, Helen S; Essex-Lopresti, Angela E; Stevenson, Freda K; Phillpotts, Robert J http://biblioteca.universia.net/ficha.do?id=18182798 Carralot, Jean-Philippe; Weide, Benjamin; Schoor, Oliver; Probst, Jochen; Scheel, Birgit; Teufel, Regina; Hoerr, Ingmar; Garbe, Claus; Rammensee, Hans-Georg; Pascolo, Steve