http://biblioteca.universia.net/html_bura/verColeccion/params/id/37077.html Mostrando recursos 1 - 20 de 291,540 es http://biblioteca.universia.net/img/logotipo.jpg http://biblioteca.universia.net/ http://biblioteca.universia.net/html_bura/ficha/params/title/two-stage-association-study-and-meta-analysis-of-mitochondrial-dna/id/56685383.html OBJECTIVES: Previous associations between mitochondrial DNA (mtDNA) and idiopathic Parkinson disease (PD) have been inconsistent and contradictory. Our aim was to resolve these inconsistencies and determine whether mtDNA has a significant role in the risk of developing PD. METHODS: Two-stage genetic association study of 138 common mtDNA variants in 3,074 PD cases and 5,659 ethnically matched controls followed by meta-analysis of 6,140 PD cases and 13,280 controls. RESULTS: In the association ... Hudson, G; Nalls, M; Evans, JR; Breen, DP; Winder-Rhodes, S; Morrison, KE; Morris, HR; Williams-Gray, CH; Barker, RA; Singleton, AB; Hardy, J; Wood, NE; Burn, DJ; Chinnery, PF http://biblioteca.universia.net/html_bura/ficha/params/title/defining-the-epsilon-sarcoglycan-sgce-gene-phenotypic-signature-in-myoclonus/id/56685382.html Mutations or exon deletions of the epsilon-sarcoglycan (SGCE) gene cause myoclonus-dystonia (M-D), but a subset of M-D patients are mutation-negative and the sensitivity and specificity of current genetic testing criteria are unknown. We screened 46 newly enrolled M-D patients for SGCE mutations and deletions; moreover, 24 subjects previously testing negative for SGCE mutations underwent gene dosage analysis. In our combined cohorts, we calculated sensitivity, specificity, positive and negati... Carecchio, M; Magliozzi, M; Copetti, M; Ferraris, A; Bernardini, L; Bonetti, M; Defazio, G; Edwards, MJ; Torrente, I; Pellegrini, F; Comi, C; Bhatia, KP; Valente, EM http://biblioteca.universia.net/html_bura/ficha/params/title/investigating-the-acoustic-response-of-gold-nanoparticle-coated-microbubbles/id/56685381.html Recent work has shown that incorporating solid nanoparticles into the coatings of contrast agent microbubbles can be used to control their stability and to provide other functional characteristics for example in multimodality imaging. The aim of this study was to investigate the influence of nanoparticle characteristics and concentration on the response of the microbubbles to ultrasound excitation. Theoretical models were first derived to simulate the effects of adsorbing different types and ... Azmin, M; Rademeyer, P; Mohamedi, G; Edirisinghe, M; Liz-Marzan, L; Stride, E http://biblioteca.universia.net/html_bura/ficha/params/title/sparse-coding-can-predict-primary-visual-cortex-receptive-field-changes/id/56685380.html Receptive fields acquired through unsupervised learning of sparse representations of natural scenes have similar properties to primary visual cortex (V1) simple cell receptive fields. However, what drives in vivo development of receptive fields remains controversial. The strongest evidence for the importance of sensory experience in visual development comes from receptive field changes in animals reared with abnormal visual input. However, most sparse coding accounts have considered only norm... Hunt, JJ; Dayan, P; Goodhill, GJ http://biblioteca.universia.net/html_bura/ficha/params/title/epilepsy-treatment-paradigm-shift-is-urgently-need/id/56685379.html Epilepsy affects between 5 and 10 people in a 1,000 and carries considerable morbidity and premature mortality. The complex inheritance pattern of a lowered seizure threshold is not fully understood but is likely to be polygenic. In the majority of people with epilepsy, we do not understand the pathophysiology, how a seizure is triggered, and how it can be prevented. In the centennial year of the discovery of the antiepileptic properties of phenobarbital, we have over 20 antiepileptic drugs; ... Bartmann, AP; Sander, JW http://biblioteca.universia.net/html_bura/ficha/params/title/active-case-finding-for-tuberculosis-among-high-risk-groups-in/id/56685378.html Zenner, D; Southern, J; Van Hest, R; DeVries, G; Stagg, HR; Antoine, D; Abubakar, I http://biblioteca.universia.net/html_bura/ficha/params/title/commentary-on-letters-from-ainsworth-contesting-the-organization-of-attachment/id/56685377.html Fonagy, P http://biblioteca.universia.net/html_bura/ficha/params/title/new-beginnings-for-mothers-and-babies-in-prison-cluster-randomized/id/56685376.html Mothers in prison represent a high-risk parenting population. New Beginnings is an attachment-based group intervention designed specifically for mothers and babies in prison. This cluster randomized trial examined the outcomes for 88 mothers and babies participating in the New Beginnings program and 75 dyads residing in prisons where the intervention did not take place. Outcomes were measured in terms of parental reflective functioning, the quality of parent-infant interaction, maternal depre... Sleed, M; Baradon, T; Fonagy, P http://biblioteca.universia.net/html_bura/ficha/params/title/the-state-of-the-evidence-base-for-psychodynamic-psychotherapy-for/id/56685375.html This article reviews outcomes of psychodynamic psychotherapy (PP) for children and adolescents reported in articles identified by a comprehensive review of the literature on treatment evaluations of psychological and medical interventions for mental disorders in pediatric populations. The review identified 48 reports based on 33 studies. While there is evidence of substantial clinical gains associated with PP, in almost all the studies, when contrasted with family-based interventions, PP fare... Palmer, R; Nascimento, LN; Fonagy, P http://biblioteca.universia.net/html_bura/ficha/params/title/attachment-related-mentalization-moderates-the-relationship-between-psychopathic-traits-and/id/56685374.html The lack of affective responsiveness to others' mental states - one of the hallmarks of psychopathy - is thought to give rise to increased interpersonal aggression. Recent models of psychopathy highlight deficits in attachment security that may, in turn, impede the development of relating to others in terms of mental states (mentalization). Here, we aimed to assess whether mentalization linked to attachment relationships may serve as a moderator for the relationship between interpersonal aggr... Taubner, S; White, LO; Zimmermann, J; Fonagy, P; Nolte, T http://biblioteca.universia.net/html_bura/ficha/params/title/genetic-differentiation-without-mimicry-shift-in-pair-of-hybridizing-heliconius/id/56685373.html Mérot, C; Mavárez, J; Evin, A; Dasmahapatra, KK; Mallet, J; Lamas, G; Joron, M http://biblioteca.universia.net/html_bura/ficha/params/title/benefits-and-adverse-events-in-younger-versus-older-patients-receiving/id/56685372.html PURPOSEThe LIVESTRONG Young Adult Alliance has conducted a meta-analysis of individual patient data from prospective neoadjuvant chemotherapy osteosarcoma studies and registries to examine the relationships of sex, age, and toxicity on survival. PATIENTS AND METHODSSuitable data sets were identified by a survey of published data reported in PubMed. The final pooled data set comprised 4,838 patients from five international cooperative groups.ResultsAfter accounting for important variables know... Collins, M; Wilhelm, M; Conyers, R; Herschtal, A; Whelan, J; Bielack, S; Kager, L; Kühne, T; Sydes, M; Gelderblom, H; Ferrari, S; Picci, P; Smeland, SE; Eriksson, M; Petrilli, AS; Bleyer, A; Thomas, DM http://biblioteca.universia.net/html_bura/ficha/params/title/real-time-fmri-neurofeedback-progress-and-challenges/id/56685371.html Sulzer, J; Haller, S; Scharnowski, F; Weiskopf, N; Birbaumer, N; Blefari, ML; Bruehl, AB; Cohen, LG; deCharms, RC; Gassert, R; Goebel, R; Herwig, U; LaConte, S; Linden, D; Luft, A; Seifritz, E; Sitaram, R http://biblioteca.universia.net/html_bura/ficha/params/title/novo-mutations-in-histone-modifying-genes-in-congenital-heart-disease/id/56685370.html Congenital heart disease (CHD) is the most frequent birth defect, affecting 0.8% of live births. Many cases occur sporadically and impair reproductive fitness, suggesting a role for de novo mutations. Here we compare the incidence of de novo mutations in 362 severe CHD cases and 264 controls by analysing exome sequencing of parent-offspring trios. CHD cases show a significant excess of protein-altering de novo mutations in genes expressed in the developing heart, with an odds ratio of 7.5 for... Zaidi, S; Choi, M; Wakimoto, H; Ma, L; Jiang, J; Overton, JD; Romano-Adesman, A; Bjornson, RD; Breitbart, RE; Brown, KK; Carriero, NJ; Cheung, YH; Deanfield, J; Depalma, S; Fakhro, KA; Glessner, J; Hakonarson, H; Italia, MJ; Kaltman, JR; Kaski, J; Kim, R; Kline, JK; Lee, T; Leipzig, J; Lopez, A; Mane, SM; Mitchell, LE; Newburger, JW; Parfenov, M; Pe'er, I; Porter, G; Roberts, AE; Sachidanandam, R; Sanders, SJ; Seiden, HS; State, MW; Subramanian, S; Tikhonova, IR; Wang, W; Warburton, D; White, PS; Williams, IA; Zhao, H; Seidman, JG; Brueckner, M; Chung, WK; Gelb, BD; Goldmuntz, E; Seidman, CE; Lifton, RP http://biblioteca.universia.net/html_bura/ficha/params/title/dysfunction-of-the-autophagy-lysosomal-degradation-pathway-is-shared-feature/id/56685369.html The past decade has witnessed huge advances in our understanding of the genetics underlying Parkinson's disease. Identifying commonalities in the biological function of genes linked to Parkinson's provides an opportunity to elucidate pathways that lead to neuronal degeneration and eventually to disease. We propose that the genetic forms of Parkinson's disease largely associated with α-synuclein-positive neuropathology (SNCA, LRRK2, and GBA) are brought together by involvement in the autophagy... Manzoni, C; Lewis, PA http://biblioteca.universia.net/html_bura/ficha/params/title/phase-ii-single-arm-study-of-irinotecan-in-combination-with/id/56685368.html Hargrave, D; Geoerger, B; Frappaz, D; Pietsch, T; Gesner, L; Cisar, L; Breazna, A; Dorman, A; Cruz-Martinez, O; Fuster, JL; Rialland, X; Icher, C; Leblond, P; Ashley, D; Perilongo, G; Elliott, M; English, M; Clausen, N; Grill, J http://biblioteca.universia.net/html_bura/ficha/params/title/environmental-tobacco-smoke-and-airway-obstruction-in-children-with-sickle/id/56685367.html ABSTRACT BACKGROUND: The contribution of environmental tobacco smoke exposure (ETS) to pulmonary morbidity in children with sickle cell anemia (SCA) is poorly understood. We tested the hypothesis that children with SCA and ETS would have an increased prevalence of obstructive lung disease and respiratory symptoms compared to children with SCA but without ETS. METHODS: Parent-report of ETS and respiratory symptom frequency were obtained for 245 children with SCA as part of a multi-center prosp... Cohen, RT; Strunk, RC; Field, JJ; Rosen, CL; Kirkham, FJ; Redline, S; Stocks, J; Rodeghier, MJ; Debaun, MR http://biblioteca.universia.net/html_bura/ficha/params/title/erratum-transsylvian-selective-amygdalohippocampectomy-in-children-with-hippocampal-sclerosis-seizure/id/56685366.html Beaton, AE; Durnford, A; Heffer-Rahn, PE; Kirkham, F; Griffin, A; Gray, WP http://biblioteca.universia.net/html_bura/ficha/params/title/arc-syndrome-due-to-vipar-mutation-is-another-cause-of/id/56685365.html Ackermann, O; Gonzales, E; Keller, M; Guettier, C; Gissen, P; Jacquemin, E http://biblioteca.universia.net/html_bura/ficha/params/title/print-head-design-and-control-for-electrohydrodynamic-printing-of-silk/id/56685364.html Hashimdeen, SH; Miodownik, M; Edirisinghe, MJ